Key Role of Overweight and Obesity on Knee Osteoarthritis

The increase in the global prevalence of Osteoarthritis (OA) is attributed not only to longer life expectancy but also to lifestyle-related risk factors such as obesity.

This edition of the OA DIGEST explores the influence of overweight and obesity on Knee Osteoarthritis (KOA), which are modifiable risk factors offering a chance for non-pharmacological interventions.

It reviews the mechanisms through which overweight and obesity impact KOA, with a focus on mechanical stress and inflammatory response, and provides recommendations for managing these risk factors.

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